Lawesson's reagent → HCID 86671893, compound

HRID 331171Notes

Reaction equation

HRID 331171 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([C:10]3[C:11]([F:30])=[CH:12][C:13]([F:29])=[C:14]([C@:16]4([CH3:28])[C:22]([F:24])([F:23])[C:21]([CH3:26])([CH3:25])[O:20][CH2:19][C:18](=O)[NH:17]4)[CH:15]=3)=[N:7][C:6]=2[CH:31]=1.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:41])=CC=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([C:10]3[C:11]([F:30])=[CH:12][C:13]([F:29])=[C:14]([C@:16]4([CH3:28])[C:22]([F:24])([F:23])[C:21]([CH3:26])([CH3:25])[O:20][CH2:19][C:18](=[S:41])[NH:17]4)[CH:15]=3)=[N:7][C:6]=2[CH:31]=1

Participants

3

Reactant 2

HCID 87949Lawesson's reagentHCID 68380096HCID 68380096, compound

Product 1

HCID 86671893HCID 86671893, compound

Procedure

In a manner analogous to that described in Example 2b), the reaction of (R)-5-[5-(5-chloro-benzooxazol-2-yl)-2,4-difluoro-phenyl]-6,6-difluoro-5,7,7-trimethyl-[1,4]oxazepan-3-one (35 mg, 77 μmol) with Lawesson's reagent (34 mg, 84 μmol) yielded the title compound in quantitative yield as a white powder. MS (ISP): m/z=473.0 [M+H]+.

Sources & evidence

ORD record
ord-0c616c32d5b046b3a4fb50373bd00feb
Source dataset
uspto-grants-2014_11
Patent number
US08877744B2

Reaction notes

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