Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 331204생성일: 2026년 10월 27일
2,5-Dimethoxyaniline → n-[3-(2,5-Dimethoxy-phenylamino)-quinoxalin-2-yl]-3-fluorobenzenesulfonamide
https://huagongshe.com/reaction/331204
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2,5-Dimethoxyaniline | HCID 7613 | — |
| 반응물 | N-(3-chloroquinoxalin-2-yl)-3-fluorobenzenesulfonamide | HCID 57625365 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | n-[3-(2,5-Dimethoxy-phenylamino)-quinoxalin-2-yl]-3-fluorobenzenesulfonamide | HCID 16045303 | 97% |
반응 단계
N-(3-chloroquinoxalin-2-yl)-3-fluorobenzenesulfonamide (125 mg, 0.4 mmole) and 2,5-dimethoxyaniline (170.4 mg, 1.1 mmole) are taken in 0.5 ml of EtOH and the resulting suspension is stirred at 100° C. in an orbital shaker, overnight. The precipitate obtained is filtered and washed with EtOH then ether to afford the title compound as a dark green solid (163 mg, 97%). HPLC (max plot) 96%, rt. 4.88 min. LC/MS: (ES+): 455.2.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08877757B2 |
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| 출처 데이터셋 | uspto-grants-2014_11 |
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| ORD ID | ord-a83bbf3d0be343b4a505ad412e35ce40 |
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| 출처 메모 | uspto-grants-2014_11 |
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