HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-{3-(4-fluoro-1-indan-1-ylpiperidin-4-yl)-2,3-dihydro-2-oxo-benzimidazol-1-yl}-N-methylacetamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Hydrogen chloride-ethyl acetate | HCID 21866389 | — |
| Reactant | 1-(4-fluoro-1-indan-1-ylpiperidin-4-yl)-1,3-dihydro-2H-benzimidazol-2-one | HCID 68701311 | — |
| Reactant | 2-{3-(4-fluoro-1-indan-1-ylpiperidin-4-yl)-2,3-dihydro-2-oxo-benzimidazol-1-yl}-N-methylacetamide | HCID 68702013 | — |
| Product | 2-{3-(4-fluoro-1-indan-1-ylpiperidin-4-yl)-2,3-dihydro-2-oxo-benzimidazol-1-yl}-N-methylacetamide hydrochloride | HCID 68705548 | — |
Reaction Steps
In the same manner as in Example 2 and using 1-(4-fluoro-1-indan-1-ylpiperidin-4-yl)-1,3-dihydro-2H-benzimidazol-2-one, 2-{3-(4-fluoro-1-indan-1-ylpiperidin-4-yl)-2,3-dihydro-2-oxo-benzimidazol-1-yl}-N-methylacetamide was synthesized, which was then converted to hydrochloride with 4N hydrochloric acid-ethyl acetate solution to give the title compound as a pale-yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08877779B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-76954f1901f54e50953ac477c901df15 |
| Source note | uspto-grants-2014_11 |