反应详情

Dimethyl 2-[2-(2-fluorophenyl)ethyl]malonate, sodium hydroxide (22.7 g), ethanol (150 ml) and water (100 ml) were heated under reflux for 1.5 hr. The reaction mixture was concentrated under reduced pressure, and the residue was acidified with hydrochloric acid, and extracted with chloroform. The extract was washed with water and saturated brine, dried over magnesium sulfate, and concentrated under reduced pressure to give 4-(2-fluorophenyl)butanoic acid.

1. temperatureunder reflux for 1.5 hr
2. concentrationThe reaction mixture was concentrated under reduced pressure
3. extractionextracted with chloroform
4. washThe extract was washed with water and saturated brine
5. dry with materialdried over magnesium sulfate
6. concentrationconcentrated under reduced pressure