反应详情

To a solution of ethyl (5-fluoronaphthalen-1-yl)acetate (5.96 g) in ethanol (50 mL) was added 1N sodium hydroxide (50 mL), and the mixture was stirred at room temperature for 2 hr. The reaction mixture was concentrated under reduced pressure, the obtained residue was poured into water, and the mixture was washed with ethyl acetate. The aqueous layer was acidified with 1N hydrochloric acid, and extracted with chloroform, and the extract was washed with water and saturated brine, dried is over magnesium sulfate, and concentrated under reduced pressure to give (5-fluoronaphthalen-1-yl)acetic acid (4.34 g). The title compound was obtained according to the method of Example 103 and using (5-fluoronaphthalen-1-yl)acetic acid.

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. additionthe obtained residue was poured into water
3. washthe mixture was washed with ethyl acetate
4. extractionextracted with chloroform
5. washthe extract was washed with water and saturated brine
6. customdried
7. concentrationconcentrated under reduced pressure