Potassium Carbonate → 2-bromo-6-hydroxy-3-phenyl-1H-inden-1-one

HRID 331263ノート

反応式

HRID 331263 の反応式
C([O:4][C:5]1[CH:13]=[C:12]2[C:8]([C:9]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[C:10]([Br:15])[C:11]2=[O:14])=[CH:7][CH:6]=1)(=O)C.C([O-])([O-])=O.[K+].[K+]>CO.CCOC(C)=O>[Br:15][C:10]1[C:11](=[O:14])[C:12]2[C:8]([C:9]=1[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[CH:7][CH:6]=[C:5]([OH:4])[CH:13]=2

参加物

5

反応物 2

HCID 11430Potassium CarbonateHCID 703132412-Bromo-1-oxo-3-phenyl-1H-inden-6-yl acetate

生成物 1

HCID 703061762-bromo-6-hydroxy-3-phenyl-1H-inden-1-one収率 93%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8857Ethyl Acetate溶媒

実験手順

2-Bromo-1-oxo-3-phenyl-1H-inden-6-yl acetate (24 g, 70.0 mmol) obtained in Step 4 was placed into a flask and dissolved in MeOH (350 mL). The solution was charged with K2CO3(11.64 g, 1.2 eq) and stirred at room temperature for 2 h. The reaction mixture was diluted with EtOAc and washed with a brine solution. The organic layer was dried over MgSO4 and concentrated in vacuo to give the desired product (19.5 g, 93%).

後処理

  1. washwashed with a brine solution
  2. dry with materialThe organic layer was dried over MgSO4
  3. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-42b5f20ca7da4b75866caa7b00176370
出典データセット
uspto-grants-2014_11
特許番号
US08877747B2

反応ノート

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