3-(4-Fluorophenyl)-2,3-dihydro-6-hydroxyinden-1-one → 1-(4-Fluorophenyl)-2,3-dihydro-3-oxo-1H-inden-5-yl acetate

HRID 331268Notes

Reaction equation

HRID 331268 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[C:16]3[C:11](=[CH:12][C:13]([OH:17])=[CH:14][CH:15]=3)[C:10](=[O:18])[CH2:9]2)=[CH:4][CH:3]=1.[OH:19][C:20]1C=C2C(C(C3C=CC=CC=3)CC2=O)=C[CH:21]=1>>[C:20]([O:17][C:13]1[CH:12]=[C:11]2[C:16](=[CH:15][CH:14]=1)[CH:8]([C:5]1[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=1)[CH2:9][C:10]2=[O:18])(=[O:19])[CH3:21]

Participants

3

Reactant 2

HCID 703048613-(4-Fluorophenyl)-2,3-dihydro-6-hydroxyinden-1-oneHCID 703075012,3-Dihydro-6-hydroxy-3-phenylinden-1-one

Product 1

HCID 703105491-(4-Fluorophenyl)-2,3-dihydro-3-oxo-1H-inden-5-yl acetateYield 99%

Procedure

The procedure of Step 3 of Example 1 was repeated except for using 3-(4-fluorophenyl)-2,3-dihydro-6-hydroxyinden-1-one obtained in Step 2 as a starting material instead of 2,3-dihydro-6-hydroxy-3-phenylinden-1-one and being stirred for 2 h to obtain the title compound (99%).

Sources & evidence

ORD record
ord-77fe603db6614a03aafacf5877775584
Source dataset
uspto-grants-2014_11
Patent number
US08877747B2

Reaction notes

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