(Pyrimidin-5-yl)boronic acid → 6-(2-morpholinoethoxy)-3-(4-fluorophenyl)-2-(pyrimidin-5-yl)-1H-inden-1-one

Participants

Reaction Steps

The procedure of Step 7 of Example 1 was repeated except for using 6-(2-morpholinoethoxy)-2-bromo-3-(4-fluorophenyl)-1H-inden-1-one obtained in Step 6 of Example 24 as a starting material instead of 6-(2-morpholinoethoxy)-2-bromo-3-phenyl-1H-inden-1-one, 5-pyrimidinylboronic acid instead of 3-pyridinylboronic acid, and being purified by silica gel column chromatography (acetone/hexanes=1:1) to obtain the title compound (96%).

Provenance & Evidence