3,4-Difluorobenzeneboronic acid → 6-(2-morpholinoethoxy)-2-(3,4-difluorophenyl)-3-(4-fluorophenyl)-1H-inden-1-one

Participants

Reaction Steps

The procedure of Step 7 of Example 1 was repeated except for using 6-(2-morpholinoethoxy)-2-bromo-3-(4-fluorophenyl)-1H-inden-1-one obtained in Step 6 of Example 24 as a starting material instead of 6-(2-morpholinoethoxy)-2-bromo-3-phenyl-1H-inden-1-one, 3,4-difluorophenylboronic acid instead of 3-pyridinylboronic acid, and being purified by silica gel column chromatography (acetone/hexanes=2:3) to obtain the title compound (81%).

Provenance & Evidence