T5637827 → 3-(4-Chlorophenyl)-2,3-dihydro-6-hydroxyinden-1-one

HRID 331273Notes

Reaction equation

HRID 331273 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5](/[CH:8]=[CH:9]/[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([OH:18])[CH:13]=2)=[O:11])=[CH:4][CH:3]=1.OC1C=C(C(=O)/C=C/C2C=CC=CC=2)C=CC=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[C:17]3[C:12](=[CH:13][C:14]([OH:18])=[CH:15][CH:16]=3)[C:10](=[O:11])[CH2:9]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 5356382T5637827HCID 6173882(E)-3-(4-chlorophenyl)-1-(3-hydroxyphenyl)prop-2-en-1-one

Product 1

HCID 703074443-(4-Chlorophenyl)-2,3-dihydro-6-hydroxyinden-1-oneYield 48%

Procedure

The procedure of Step 2 of Example 1 was repeated except for using (E)-3-(4-chlorophenyl)-1-(3-hydroxyphenyl)prop-2-en-1-one obtained in Step 1 as a starting material instead of (E)-1-(3-hydroxyphenyl)-3-phenylprop-2-en-1-one and being stirred for 4 d to obtain the title compound (48%).

Sources & evidence

ORD record
ord-f6524d4e339b40b7981533bb95fba236
Source dataset
uspto-grants-2014_11
Patent number
US08877747B2

Reaction notes

Loading…