HuagongsheHuagongshe Chemistry Print Report · For research reference only
(Pyrimidin-5-yl)boronic acid → HCID 51002368, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (Pyrimidin-5-yl)boronic acid | HCID 2795193 | — |
| Reactant | 6-(2-morpholinoethoxy)-2-bromo-3-phenyl-1H-inden-1-one | HCID 70307620 | — |
| Reactant | 6-(2-Morpholino ethoxy)-2-bromo-3-(4-chlorophenyl)-1H-inden-1-one | HCID 70312317 | — |
| Product | HCID 51002368 | HCID 51002368 | 71% |
Reaction Steps
The procedure of Step 7 of Example 1 was repeated except for using 6-(2-morpholinoethoxy)-2-bromo-3-(4-chlorophenyl)-1H-inden-1-one obtained in Step 6 of Example 28 as a starting material instead of 6-(2-morpholinoethoxy)-2-bromo-3-phenyl-1H-inden-1-one, 5-pyrimidinylboronic acid instead of 3-pyridinylboronic acid, and being purified by silica gel column chromatography (acetone/hexanes=2:3) to obtain the title compound (71%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08877747B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-994f0f9b507d45cbb0d41bddccd54f02 |
| Source note | uspto-grants-2014_11 |