T5637827 → 3-(4-(Trifluoromethyl)phenyl)-2,3-dihydro-6-hydroxyinden-1-one

HRID 331279Notes

Reaction equation

HRID 331279 reaction equation
[F:1][C:2]([F:21])([F:20])[C:3]1[CH:8]=[CH:7][C:6](/[CH:9]=[CH:10]/[C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([OH:19])[CH:14]=2)=[O:12])=[CH:5][CH:4]=1.OC1C=C(C(=O)/C=C/C2C=CC=CC=2)C=CC=1>>[F:1][C:2]([F:20])([F:21])[C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[C:18]3[C:13](=[CH:14][C:15]([OH:19])=[CH:16][CH:17]=3)[C:11](=[O:12])[CH2:10]2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 5356382T5637827HCID 6215177(E)-3-(4-(Tri fluoromethyl)phenyl)-1-(3-hydroxyphenyl)prop-2-en-1-one

Product 1

HCID 703074073-(4-(Trifluoromethyl)phenyl)-2,3-dihydro-6-hydroxyinden-1-oneYield 38%

Procedure

The procedure of Step 2 of Example 1 was repeated except for using (E)-3-(4-(trifluoromethyl)phenyl)-1-(3-hydroxyphenyl)prop-2-en-1-one obtained in Step 1 as a starting material instead of (E)-1-(3-hydroxyphenyl)-3-phenylprop-2-en-1-one and being stirred for 5 d to obtain the title compound (38%).

Sources & evidence

ORD record
ord-73e3144c842848a1a0903f1cb3f81e48
Source dataset
uspto-grants-2014_11
Patent number
US08877747B2

Reaction notes

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