2,3-Dihydro-6-hydroxy-3-phenylinden-1-one → 1-(3,5-Difluorophenyl)-2,3-dihydro-3-oxo-1H-inden-5-yl acetate

HRID 331286Notes

Reaction equation

HRID 331286 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:9]2[C:17]3[C:12](=[CH:13][C:14]([OH:18])=[CH:15][CH:16]=3)[C:11](=[O:19])[CH2:10]2)[CH:5]=[C:6]([F:8])[CH:7]=1.[OH:20][C:21]1C=C2C(C(C3C=CC=CC=3)CC2=O)=C[CH:22]=1>>[C:21]([O:18][C:14]1[CH:13]=[C:12]2[C:17](=[CH:16][CH:15]=1)[CH:9]([C:4]1[CH:3]=[C:2]([F:1])[CH:7]=[C:6]([F:8])[CH:5]=1)[CH2:10][C:11]2=[O:19])(=[O:20])[CH3:22]

Participants

3

Reactant 2

HCID 703075012,3-Dihydro-6-hydroxy-3-phenylinden-1-oneHCID 703083363-(3,5-Difluorophenyl)-2,3-dihydro-6-hydroxyinden-1-one

Product 1

HCID 703128031-(3,5-Difluorophenyl)-2,3-dihydro-3-oxo-1H-inden-5-yl acetateYield 83%

Procedure

The procedure of Step 3 of Example 1 was repeated except for using 3-(3,5-difluorophenyl)-2,3-dihydro-6-hydroxyinden-1-one obtained in Step 2 as a starting material instead of 2,3-dihydro-6-hydroxy-3-phenylinden-1-one and being stirred for 2 h to obtain the title compound (83%).

Sources & evidence

ORD record
ord-adb50aa217ba4ef3b927cfd26ebba794
Source dataset
uspto-grants-2014_11
Patent number
US08877747B2

Reaction notes

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