反应详情

To a solution of 6-(2-morpholinoethoxy)-3-phenyl-2-(pyridin-3-yl)-1H-inden-1-one (100 mg, 0.24 mmol) obtained in Step 7 of Example 1 in CH2Cl2 (2 mL) at 10° C. was added MCPBA (21 mg, 1 eq). The mixture was stirred at room temperature for 2 h. The reaction mixture was diluted with EtOAc and washed with sat. NaHCO3, H2O, and brine. The organic layer was dried over MgSO4 and concentrated in vacuo. The residue was purified by silica gel column chromatography (MC/MeOH/NH4OH=92:7:1) to afford the title compound (14 mg, 13%).

1. washwashed with sat. NaHCO3, H2O, and brine
2. dry with materialThe organic layer was dried over MgSO4
3. concentrationconcentrated in vacuo
4. customThe residue was purified by silica gel column chromatography (MC/MeOH/NH4OH=92:7:1)