HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-(Dimethylamino)ethanol → 6-(2-(Dimethylamino)ethoxy)-3-phenyl-2-(pyridin-3-yl)-1H-inden-1-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-(Dimethylamino)ethanol | HCID 7902 | — |
| Edukt | 2-bromo-6-hydroxy-3-phenyl-1H-inden-1-one | HCID 70306176 | — |
| Edukt | 6-Hydroxy-3-phenyl-2-(pyridin-3-yl)-1H-inden-1-one | HCID 70313190 | — |
| Produkt | 6-(2-(Dimethylamino)ethoxy)-3-phenyl-2-(pyridin-3-yl)-1H-inden-1-one | HCID 51001835 | 45% |
Reaktionsschritte
The procedure of Step 6 of Example 1 was repeated except for using 6-hydroxy-3-phenyl-2-(pyridin-3-yl)-1H-inden-1-one obtained in Step 1 of Example 55 as a starting material instead of 2-bromo-6-hydroxy-3-phenyl-1H-inden-1-one, 2-(dimethylamino)ethanol instead of 4-(2-hydroxyethyl)morpholine, and being recrystallized with EtOAc to obtain the title compound (45%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08877747B2 |
| Quelldatensatz | uspto-grants-2014_11 |
| ORD ID | ord-299228a248794e1a9ec82e0398d18846 |
| Quellennotiz | uspto-grants-2014_11 |