HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Dimethylamino)-1-propanol → 6-(3-(Dimethylamino)propoxy)-3-phenyl-2-(pyridin-3-yl)-1H-inden-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Dimethylamino)-1-propanol | HCID 76646 | — |
| Reactant | 2-bromo-6-hydroxy-3-phenyl-1H-inden-1-one | HCID 70306176 | — |
| Reactant | 6-Hydroxy-3-phenyl-2-(pyridin-3-yl)-1H-inden-1-one | HCID 70313190 | — |
| Product | 6-(3-(Dimethylamino)propoxy)-3-phenyl-2-(pyridin-3-yl)-1H-inden-1-one | HCID 51001887 | 30% |
Reaction Steps
The procedure of Step 6 of Example 1 was repeated except for using 6-hydroxy-3-phenyl-2-(pyridin-3-yl)-1H-inden-1-one obtained in Step 1 of Example 55 as a starting material instead of 2-bromo-6-hydroxy-3-phenyl-1H-inden-1-one, 3-(dimethylamino)propanol instead of 4-(2-hydroxyethyl)morpholine, being stirred for 4 d, and being recrystallized with EtOAc to obtain the title compound (30%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08877747B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-ed5c4661e4ee4e56b5d718c5ec51843c |
| Source note | uspto-grants-2014_11 |