HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Dimethylamino)-1-propanol → HCID 70312572, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Dimethylamino)-1-propanol | HCID 76646 | — |
| Reactant | 2-bromo-6-hydroxy-3-phenyl-1H-inden-1-one | HCID 70306176 | — |
| Reactant | 2-Bromo-3-(3,5-difluorophenyl)-6-hydroxy-1H-inden-1-one | HCID 70316043 | — |
| Product | HCID 70312572 | HCID 70312572 | 86% |
Reaction Steps
The procedure of Step 6 of Example 1 was repeated except for using 2-bromo-3-(3,5-difluorophenyl)-6-hydroxy-1H-inden-1-one obtained in Step 5 of Example 36 as a starting material instead of 2-bromo-6-hydroxy-3-phenyl-1H-inden-1-one, 3-(dimethylamino)propanol instead of 4-(2-hydroxyethyl)morpholine, being stirred for 4 d, and being purified by silica gel column chromatography (CH2Cl2/EtOAc=1:1) to obtain the title compound (86%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08877747B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-eae0f80c0a744c8fbd68e1264d11e7f7 |
| Source note | uspto-grants-2014_11 |