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HRID331312

反应详情

EQUATION

反应方程式

HRID 331312 的结构方程式

REACTANTS

反应物

3
结构：OCCc1ccccn1
HCID7675

2-(2-Pyridyl)ethanol

C7H9NO

结构：O=C1C(Br)=C(c2ccccc2)c2ccc(O)cc21
HCID70306176

未命名化合物

结构：O=C1C(c2cccnc2)=C(c2cc(F)cc(F)c2)c2ccc(O)cc21
HCID70317432

未命名化合物

PRODUCTS

生成物

1
结构：O=C1C(c2cccnc2)=C(c2cc(F)cc(F)c2)c2ccc(OCCc3ccccn3)cc21
HCID51001937

未命名化合物

收率 45%

PROCEDURE

实验过程

The procedure of Step 6 of Example 1 was repeated except for using 3-(3,5-difluorophenyl)-6-hydroxy-2-(pyridin-3-yl)-1H-inden-1-one obtained in Step 1 of Example 61 as a starting material instead of 2-bromo-6-hydroxy-3-phenyl-1H-inden-1-one, 2-(pyridin-2-yl)ethanol instead of 4-(2-hydroxyethyl)morpholine, being stirred for 7 d, and being purified by silica gel column chromatography (CH2Cl2/EtOAc=1:4) to obtain the title compound (45%).

WORKUP

后处理

  1. custombeing purified by silica gel column chromatography (CH2Cl2/EtOAc=1:4)