反应详情

To a 10 mL round-bottomed flask, tert-butyl 4-(3-(3-(3,5-difluorophenyl)-1-oxo-2-(pyridin-3-yl)-1H-inden-6-yloxy)propyl)piperazine-1-carboxylate (107.5 mg, 0.19 mmol) obtained in Step 2 of Example 64 and CH2Cl2 (2 mL, 0.1M) were charged. Trifluoroacetic acid (0.6 mL, 40.0 eq) was added dropwise over 5 min at 0° C. After being stirred for 2 h, the mixture was quenched with H2O and washed with CH2Cl2. The aqueous layer was basicified to pH 9 with a 15% NaOH solution and extracted with CH2Cl2. The extracts were concentrated in vacuo to provide the title compound (80 mg, 93%).

1. customthe mixture was quenched with H2O
2. washwashed with CH2Cl2
3. extractionextracted with CH2Cl2
4. concentrationThe extracts were concentrated in vacuo