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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 331320Generated: October 26, 2026

tert-butyl 4-(3-(3-(3,5-difluorophenyl)-1-oxo-2-(pyridin-3-yl)-1H-inden-6-yloxy)propyl)piperazine-1-carboxylate → 3-(3,5-Difluorophenyl)-6-(2-(piperidin-4-yl)ethoxy)-2-(pyridin-3-yl)-1H-inden-1-one

https://huagongshe.com/reaction/331320

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-butyl 4-(3-(3-(3,5-difluorophenyl)-1-oxo-2-(pyridin-3-yl)-1H-inden-6-yloxy)propyl)piperazine-1-carboxylateHCID 51001940—
Reactanttert-butyl 4-(2-(3-(3,5-difluorophenyl)-1-oxo-2-(pyridin-3-yl)-1H-inden-6-yloxy)ethyl)piperidine-1-carboxylateHCID 51001989—
Product3-(3,5-Difluorophenyl)-6-(2-(piperidin-4-yl)ethoxy)-2-(pyridin-3-yl)-1H-inden-1-oneHCID 51001990—

Reaction Steps

The procedure of Step 1 of Example 66 was repeated except for using tert-butyl 4-(2-(3-(3,5-difluorophenyl)-1-oxo-2-(pyridin-3-yl)-1H-inden-6-yloxy)ethyl)piperidine-1-carboxylate obtained in Example 69 as a starting material instead of tert-butyl 4-(3-(3-(3,5-difluorophenyl)-1-oxo-2-(pyridin-3-yl)-1H-inden-6-yloxy)propyl)piperazine-1-carboxylate and being stirred for 30 min to provide the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08877747B2
Source datasetuspto-grants-2014_11
ORD IDord-de71d12c48424ace8b52146fa3e44203
Source noteuspto-grants-2014_11