HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-butyl 4-(3-(3-(3,5-difluorophenyl)-1-oxo-2-(pyridin-3-yl)-1H-inden-6-yloxy)propyl)piperazine-1-carboxylate → 3-(3,5-Difluorophenyl)-6-(2-(piperidin-4-yl)ethoxy)-2-(pyridin-3-yl)-1H-inden-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-butyl 4-(3-(3-(3,5-difluorophenyl)-1-oxo-2-(pyridin-3-yl)-1H-inden-6-yloxy)propyl)piperazine-1-carboxylate | HCID 51001940 | — |
| Reactant | tert-butyl 4-(2-(3-(3,5-difluorophenyl)-1-oxo-2-(pyridin-3-yl)-1H-inden-6-yloxy)ethyl)piperidine-1-carboxylate | HCID 51001989 | — |
| Product | 3-(3,5-Difluorophenyl)-6-(2-(piperidin-4-yl)ethoxy)-2-(pyridin-3-yl)-1H-inden-1-one | HCID 51001990 | — |
Reaction Steps
The procedure of Step 1 of Example 66 was repeated except for using tert-butyl 4-(2-(3-(3,5-difluorophenyl)-1-oxo-2-(pyridin-3-yl)-1H-inden-6-yloxy)ethyl)piperidine-1-carboxylate obtained in Example 69 as a starting material instead of tert-butyl 4-(3-(3-(3,5-difluorophenyl)-1-oxo-2-(pyridin-3-yl)-1H-inden-6-yloxy)propyl)piperazine-1-carboxylate and being stirred for 30 min to provide the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08877747B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-de71d12c48424ace8b52146fa3e44203 |
| Source note | uspto-grants-2014_11 |