T5637827 → 3-(2-Fluorophenyl)-2,3-dihydro-6-hydroxyinden-1-one

HRID 331327Notes

Reaction equation

HRID 331327 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1/[CH:8]=[CH:9]/[C:10]([C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([OH:18])[CH:13]=1)=[O:11].OC1C=C(C(=O)/C=C/C2C=CC=CC=2)C=CC=1>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[C:17]2[C:12](=[CH:13][C:14]([OH:18])=[CH:15][CH:16]=2)[C:10](=[O:11])[CH2:9]1

Participants

3

Reactant 2

HCID 5356382T5637827HCID 19562750(E)-3-(2-fluorophenyl)-1-(3-hydroxyphenyl)prop-2-en-1-one

Product 1

HCID 703082663-(2-Fluorophenyl)-2,3-dihydro-6-hydroxyinden-1-oneYield 83%

Procedure

The procedure of Step 2 of Example 1 was repeated except for using (E)-3-(2-fluorophenyl)-1-(3-hydroxyphenyl)prop-2-en-1-one obtained in Step 1 as a starting material instead of (E)-1-(3-hydroxyphenyl)-3-phenylprop-2-en-1-one, being stirred for 16 h to obtain the title compound (83%).

Sources & evidence

ORD record
ord-e11388b9358541128689dae9d7eb6f25
Source dataset
uspto-grants-2014_11
Patent number
US08877747B2

Reaction notes

Loading…