3-(3-Fluorophenyl)-2,3-dihydro-6-hydroxyinden-1-one → 1-(3-Fluorophenyl)-2,3-dihydro-3-oxo-1H-inden-5-yl acetate

HRID 331331Notes

Reaction equation

HRID 331331 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:8]2[C:16]3[C:11](=[CH:12][C:13]([OH:17])=[CH:14][CH:15]=3)[C:10](=[O:18])[CH2:9]2)[CH:5]=[CH:6][CH:7]=1.[OH:19][C:20]1C=C2C(C(C3C=CC=CC=3)CC2=O)=C[CH:21]=1>>[C:20]([O:17][C:13]1[CH:12]=[C:11]2[C:16](=[CH:15][CH:14]=1)[CH:8]([C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[CH:3]=1)[CH2:9][C:10]2=[O:18])(=[O:19])[CH3:21]

Participants

3

Reactant 2

HCID 703049273-(3-Fluorophenyl)-2,3-dihydro-6-hydroxyinden-1-oneHCID 703075012,3-Dihydro-6-hydroxy-3-phenylinden-1-one

Product 1

HCID 703155991-(3-Fluorophenyl)-2,3-dihydro-3-oxo-1H-inden-5-yl acetateYield 92%

Procedure

The procedure of Step 3 of Example 1 was repeated except for using 3-(3-fluorophenyl)-2,3-dihydro-6-hydroxyinden-1-one obtained in Step 2 as a starting material instead of 2,3-dihydro-6-hydroxy-3-phenylinden-1-one to obtain the title compound (92%).

Sources & evidence

ORD record
ord-64e87603a1db4196811ca20b42329e95
Source dataset
uspto-grants-2014_11
Patent number
US08877747B2

Reaction notes

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