T5637827 → HCID 70306128, compound

HRID 331333Notes

Reaction equation

HRID 331333 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1/[CH:9]=[CH:10]/[C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([OH:19])[CH:14]=1)=[O:12].OC1C=C(C(=O)/C=C/C2C=CC=CC=2)C=CC=1>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH:9]1[C:18]2[C:13](=[CH:14][C:15]([OH:19])=[CH:16][CH:17]=2)[C:11](=[O:12])[CH2:10]1

Participants

3

Reactant 2

HCID 5356382T5637827HCID 47104753HCID 47104753, compound

Product 1

HCID 70306128HCID 70306128, compoundYield 83%

Procedure

The procedure of Step 2 of Example 1 was repeated except for using (E)-3-(2,4-difluorophenyl)-1-(3-hydroxyphenyl)prop-2-en-1-one obtained in Step 1 as a starting material instead of (E)-1-(3-hydroxyphenyl)-3-phenylprop-2-en-1-one and being stirred for 16 h to obtain the title compound (83%).

Sources & evidence

ORD record
ord-02fb7e9bf9a94194bf39db35a2b39019
Source dataset
uspto-grants-2014_11
Patent number
US08877747B2

Reaction notes

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