HCID 70306128, compound → HCID 70312798, compound

HRID 331334Notes

Reaction equation

HRID 331334 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH:9]1[C:17]2[C:12](=[CH:13][C:14]([OH:18])=[CH:15][CH:16]=2)[C:11](=[O:19])[CH2:10]1.[OH:20][C:21]1C=C2C(C(C3C=CC=CC=3)CC2=O)=C[CH:22]=1>>[C:21]([O:18][C:14]1[CH:13]=[C:12]2[C:17](=[CH:16][CH:15]=1)[CH:9]([C:3]1[CH:4]=[CH:5][C:6]([F:8])=[CH:7][C:2]=1[F:1])[CH2:10][C:11]2=[O:19])(=[O:20])[CH3:22]

Participants

3

Reactant 2

HCID 70306128HCID 70306128, compoundHCID 703075012,3-Dihydro-6-hydroxy-3-phenylinden-1-one

Product 1

HCID 70312798HCID 70312798, compoundYield 90%

Procedure

The procedure of Step 3 of Example 1 was repeated except for using 3-(2,4-difluorophenyl)-2,3-dihydro-6-hydroxyinden-1-one obtained in Step 2 as a starting material instead of 2,3-dihydro-6-hydroxy-3-phenylinden-1-one to obtain the title compound (90%).

Sources & evidence

ORD record
ord-d623fb5ea8804c16b37d606c37c84b2a
Source dataset
uspto-grants-2014_11
Patent number
US08877747B2

Reaction notes

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