HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluoro-4-methoxyphenylboronic acid → HCID 70308331, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluoro-4-methoxyphenylboronic acid | HCID 2782194 | — |
| Reactant | 6-(2-morpholinoethoxy)-2-bromo-3-phenyl-1H-inden-1-one | HCID 70307620 | — |
| Reactant | 2-Bromo-3-(3,5-difluorophenyl)-6-(2-(4-(methylsulfonyl)piperazin-1-yl)ethoxy)-1H-inden-1-one | HCID 70310094 | — |
| Product | HCID 70308331 | HCID 70308331 | 71% |
Reaction Steps
The procedure of Step 7 of Example 1 was repeated except for using 2-bromo-3-(3,5-difluorophenyl)-6-{2-[4-(methylsulfonyl)piperazin-1-yl]ethoxy}-1H-inden-1-one obtained in Step 1 of Example 96 as a starting material instead of 6-(2-morpholinoethoxy)-2-bromo-3-phenyl-1H-inden-1-one, 3-fluoro-4-methoxyphenylboronic acid instead of 3-pyridinylboronic acid, and being purified by silica gel column chromatography (EtOAc/CH2Cl2=1:1) to obtain the title compound (71%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08877747B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-11e9a2bbbaa54d5aac0f54682697c07a |
| Source note | uspto-grants-2014_11 |