HRID331359

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2782194

未命名化合物

结构：O=C1C(Br)=C(c2ccccc2)c2ccc(OCCN3CCOCC3)cc21

HCID70307620

未命名化合物

结构：CC(C)(C)OC(=O)N1CCN(CCCOc2ccc3c(c2)C(=O)C(Br)=C3c2cc(F)cc(F)c2)CC1

HCID70311966

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(C2=C(c3cc(F)cc(F)c3)c3ccc(OCCCN4CCN(C(=O)OC(C)(C)C)CC4)cc3C2=O)cc1F

HCID70313706

未命名化合物

PROCEDURE

实验过程

The procedure of Step 7 of Example 1 was repeated except for using t-butyl 4-(3-(2-bromo-3-(3,5-difluorophenyl)-1-oxo-1H-inden-6-yloxy)propyl)piperazine-1-carboxylate obtained in Step 1 of Example 104 as a starting material instead of 6-(2-morpholino ethoxy)-2-bromo-3-phenyl-1H-inden-1-one, 3-fluoro-4-methoxyphenylboronic acid instead of 3-pyridinylboronic acid, and being purified by silica gel column chromatography (EtOAc/hexanes=1:1) to obtain the title compound.

WORKUP

后处理

custombeing purified by silica gel column chromatography (EtOAc/hexanes=1:1)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b7d1e84ba569472c8c19d1550f8bab5b
来源数据集: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08877747B2
来源说明: uspto-grants-2014_11

反应 SMILES

Br[C:2]1[C:3](=[O:36])[C:4]2[C:9]([C:10]=1[C:11]1[CH:16]=[C:15]([F:17])[CH:14]=[C:13]([F:18])[CH:12]=1)=[CH:8][CH:7]=[C:6]([O:19][CH2:20][CH2:21][CH2:22][N:23]1[CH2:28][CH2:27][N:26]([C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])[CH2:25][CH2:24]1)[CH:5]=2.O1CCN(CCOC2C=C3C(C(C4C=CC=CC=4)=C(Br)C3=O)=CC=2)CC1.[F:63][C:64]1[CH:65]=[C:66](B(O)O)[CH:67]=[CH:68][C:69]=1[O:70][CH3:71]>>[F:63][C:64]1[CH:65]=[C:66]([C:2]2[C:3](=[O:36])[C:4]3[C:9]([C:10]=2[C:11]2[CH:16]=[C:15]([F:17])[CH:14]=[C:13]([F:18])[CH:12]=2)=[CH:8][CH:7]=[C:6]([O:19][CH2:20][CH2:21][CH2:22][N:23]2[CH2:24][CH2:25][N:26]([C:29]([O:31][C:32]([CH3:34])([CH3:33])[CH3:35])=[O:30])[CH2:27][CH2:28]2)[CH:5]=3)[CH:67]=[CH:68][C:69]=1[O:70][CH3:71]