Trifluoroacetic acid → 3-(3,5-Difluorophenyl)-2-(3-fluoro-4-methoxyphenyl)-6-(3-(piperazin-1-yl)propoxy)-1H-inden-1-one

Participants

Reaction Steps

To a solution of tert-butyl 4-(3-(2-(3-fluoro-4-methoxyphenyl)-3-(3,5-difluorophenyl)-1-oxo-1H-inden-6-yloxy)propyl)piperazine-1-carboxylate (96 mg, 0.2 mmol) obtained in Step 1 in CH2Cl2 was added trifluoroacetic acid (20 eq, 2.4 mmol). After being stirred for 1 h, the mixture was diluted with CH2Cl2 and basicified to pH 9 with a 3N NaOH solution. The organic layer was washed with H2O and brine, dried over MgSO4, and concentrated in vacuo to provide the title compound.

Provenance & Evidence