Quinoline-3-boronic acid → 3-(2,4-difluorophenyl)-6-{3-[4-(methylsulfonyl)piperazin-1-yl]propoxy}-2-(quinolin-3-yl)-1H-inden-1-one

Participants

Reaction Steps

The procedure of Step 7 of Example 1 was repeated except for using 2-bromo-3-(2,4-difluorophenyl)-6-[3-(4-(methylsulfonyl)piperazin-1-yl)propoxy]-1H-inden-1-one obtained in Step 1 of Example 108 as a starting material instead of 6-(2-morpholinoethoxy)-2-bromo-3-phenyl-1H-inden-1-one and 3-quinolinylboronic acid instead of 3-pyridinylboronic acid to obtain the title compound (83%).

Provenance & Evidence