HRID331372

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2734368

2-Methoxy-5-pyridineboronic acid

C6H8BNO3

结构：O=C1C(Br)=C(c2ccccc2)c2ccc(OCCN3CCOCC3)cc21

HCID70307620

未命名化合物

结构：O=C1C(Br)=C(c2ccc(F)cc2F)c2ccc(OCCN3CCS(=O)(=O)CC3)cc21

HCID70314038

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(C2=C(c3ccc(F)cc3F)c3ccc(OCCN4CCS(=O)(=O)CC4)cc3C2=O)cn1

HCID51002193

未命名化合物

收率 67%

PROCEDURE

实验过程

The procedure of Step 7 of Example 1 was repeated except for using 2-bromo-3-(2,4-difluorophenyl)-6-[2-(1,1-dioxothiomorpholin-4-yl)ethoxy]-1H-inden-1-one obtained in Step 1 of Example 112 as a starting material instead of 6-(2-morpholinoethoxy)-2-bromo-3-phenyl-1H-inden-1-one and 6-methoxy-3-pyridinylboronic acid instead of 3-pyridinylboronic acid to obtain the title compound (67%).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0f1e9dc783a54891946f970c40e2a567
来源数据集: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08877747B2
来源说明: uspto-grants-2014_11

反应 SMILES

Br[C:2]1[C:3](=[O:30])[C:4]2[C:9]([C:10]=1[C:11]1[CH:16]=[CH:15][C:14]([F:17])=[CH:13][C:12]=1[F:18])=[CH:8][CH:7]=[C:6]([O:19][CH2:20][CH2:21][N:22]1[CH2:27][CH2:26][S:25](=[O:29])(=[O:28])[CH2:24][CH2:23]1)[CH:5]=2.O1CCN(CCOC2C=C3C(C(C4C=CC=CC=4)=C(Br)C3=O)=CC=2)CC1.[CH3:57][O:58][C:59]1[N:64]=[CH:63][C:62](B(O)O)=[CH:61][CH:60]=1>>[F:18][C:12]1[CH:13]=[C:14]([F:17])[CH:15]=[CH:16][C:11]=1[C:10]1[C:9]2[C:4](=[CH:5][C:6]([O:19][CH2:20][CH2:21][N:22]3[CH2:27][CH2:26][S:25](=[O:28])(=[O:29])[CH2:24][CH2:23]3)=[CH:7][CH:8]=2)[C:3](=[O:30])[C:2]=1[C:62]1[CH:63]=[N:64][C:59]([O:58][CH3:57])=[CH:60][CH:61]=1