3-(3,5-Difluorophenyl)-5-methoxy-2-(pyridin-3-yl)-1H-inden-1-one → 5-Hydroxy-3-phenyl-2-(pyridin-4-yl)-1H-inden-1-one

HRID 331392Notes

Reaction equation

HRID 331392 reaction equation
C[O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[C:7]([C:13]1[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=1)=[C:6]2[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.FC1C=C(C2C3C(=CC=C(OC)C=3)C(=O)C=2C2C=NC=CC=2)C=C(F)C=1>>[OH:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[C:7]([C:13]1[CH:14]=[CH:15][N:16]=[CH:17][CH:18]=1)=[C:6]2[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 703136143-(3,5-Difluorophenyl)-5-methoxy-2-(pyridin-3-yl)-1H-inden-1-oneHCID 703159155-Methoxy-3-phenyl-2-(pyridin-4-yl)-1H-inden-1-one

Product 1

HCID 703135045-Hydroxy-3-phenyl-2-(pyridin-4-yl)-1H-inden-1-oneYield 88%

Procedure

The procedure of Step 5 of Example 128 was repeated except for using 5-methoxy-3-phenyl-2-(pyridin-4-yl)-1H-inden-1-one obtained in Step 1 as a starting material instead of 3-(3,5-difluorophenyl)-5-methoxy-2-(pyridin-3-yl)-1H-inden-1-one to obtain the title compound (88%).

Sources & evidence

ORD record
ord-c01d8cff786c4cca90ab935174bbe8b3
Source dataset
uspto-grants-2014_11
Patent number
US08877747B2

Reaction notes

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