3-(3,5-Difluorophenyl)-5-methoxy-2-(pyridin-3-yl)-1H-inden-1-one → HCID 70314913, compound

HRID 331396Notes

Reaction equation

HRID 331396 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:9]2[C:10](=[O:26])[C:11]3[C:16]([C:17]=2[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[CH:15][C:14]([O:24]C)=[CH:13][CH:12]=3)[CH:5]=[CH:6][C:7]=1[CH3:8].FC1C=C(C2C3C(=CC=C(OC)C=3)C(=O)C=2C2C=NC=CC=2)C=C(F)C=1>>[F:1][C:2]1[CH:3]=[C:4]([C:9]2[C:10](=[O:26])[C:11]3[C:16]([C:17]=2[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[CH:15][C:14]([OH:24])=[CH:13][CH:12]=3)[CH:5]=[CH:6][C:7]=1[CH3:8]

Participants

3

Reactant 2

HCID 703136143-(3,5-Difluorophenyl)-5-methoxy-2-(pyridin-3-yl)-1H-inden-1-oneHCID 703171212-(3-Fluoro-4-methylphenyl)-5-Methoxy-3-phenyl-1H-inden-1-one

Product 1

HCID 70314913HCID 70314913, compoundYield 88%

Procedure

The procedure of Step 5 of Example 128 was repeated except for using 2-(3-fluoro-4-methylphenyl)-5-methoxy-3-phenyl-1H-inden-1-one obtained in Step 1 as a starting material instead of 3-(3,5-difluorophenyl)-5-methoxy-2-(pyridin-3-yl)-1H-inden-1-one to obtain the title compound (88%).

Sources & evidence

ORD record
ord-c19e75880c16406e9fcf9b985dab5b08
Source dataset
uspto-grants-2014_11
Patent number
US08877747B2

Reaction notes

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