Potassium Carbonate → 3-(3,5-difluorophenyl)-5-[2-(4-(methylsulfonyl)piperazin-1-yl)ethoxy]-2-(pyridin-3-yl)-1H-inden-1-one

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-(3,5-difluorophenyl)-5-hydroxy-2-(pyridin-3-yl)-1H-inden-1-one (60 mg, 0.18 mmol) obtained in Step 5 of Example 128 in DMF (2 mL) was added K2CO3(75 mg, 0.54 mmol) and methylsulfonyl 2-(4-(methylsulfonyl)piperazin-1-yl)ethyl ether (77 mg, 0.27 mmol). The mixture was heated to 80° C. for 3 h and cooled to room temperature. The resulting solution was diluted with H2O (5 mL) and extracted with EtOAc (5 mL×3). The extracts were washed with H2O and brine, dried over MgSO4, and concentrated in vacuo. The residue was purified by silica gel column chromatography (2% MeOH/CH2Cl2) to afford the title compound (65 mg, 69%).

Provenance & Evidence