3-Methoxypropionic acid → HCID 178495577, compound

HRID 331404Notes

Reaction equation

HRID 331404 reaction equation
Cl.Cl.[O:3]1[C:8]2=[CH:9][CH:10]=[CH:11][C:7]2=[C:6]([CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][N:13]2[CH2:18][CH2:19][C@H:20]2[CH2:25][CH2:24][C@H:23]([NH2:26])[CH2:22][CH2:21]2)[CH:5]=[CH:4]1.[CH3:27][O:28][CH2:29][CH2:30][C:31](O)=[O:32]>>[O:3]1[C:8]2=[CH:9][CH:10]=[CH:11][C:7]2=[C:6]([CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][N:13]2[CH2:18][CH2:19][C@H:20]2[CH2:21][CH2:22][C@H:23]([NH:26][C:31](=[O:32])[CH2:30][CH2:29][O:28][CH3:27])[CH2:24][CH2:25]2)[CH:5]=[CH:4]1

Participants

3

Reactant 2

HCID 1344423-Methoxypropionic acidHCID 178478712HCID 178478712, compound2×

Product 1

HCID 178495577HCID 178495577, compound

Procedure

The title compound, off-white solid (74 mg, 72%), MS (ISP) m/z=413.4 [(M+H)+], mp 154° C., was prepared in accordance with the general method of example 1 from trans-4-[2-(4-benzofuran-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl-amine dihydrochloride (intermediate A) (100 mg, 0.25 mmol) and 3-methoxypropionic acid.

Sources & evidence

ORD record
ord-7182e3293e4a45588f91c30d3c84ac56
Source dataset
uspto-grants-2014_11
Patent number
US08877778B2

Reaction notes

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