反应详情

The title compound, off-white solid (85 mg, 75%), MS (ISP) m/z=457.5 [(M+H)+], mp 192° C., was prepared in accordance with the general method of example 1 from trans-4-{2-[4-(2,3-dihydro-benzofuran-4-yl)-piperidin-1-yl]-ethyl}-cyclohexylamine dihydrochloride (intermediate B) (100 mg, 0.25 mmol) and rac-(1,4-dioxan-2-yl)-acetic acid.