2-Isopropoxy-5-methylsulfonylbenzoic acid → (4-Benzoxazol-2-yl-piperazin-1-yl)-(2-isopropoxy-5-methanesulfonyl-phenyl)-methanone

HRID 33142Notes

Reaction equation

HRID 33142 reaction equation
[CH:1]([O:4][C:5]1[CH:13]=[CH:12][C:11]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:10][C:6]=1[C:7]([OH:9])=O)([CH3:3])[CH3:2].Cl.[N:19]1([C:25]2[O:26][C:27]3[CH:33]=[CH:32][CH:31]=[CH:30][C:28]=3[N:29]=2)[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>>[O:26]1[C:27]2[CH:33]=[CH:32][CH:31]=[CH:30][C:28]=2[N:29]=[C:25]1[N:19]1[CH2:20][CH2:21][N:22]([C:7]([C:6]2[CH:10]=[C:11]([S:14]([CH3:17])(=[O:16])=[O:15])[CH:12]=[CH:13][C:5]=2[O:4][CH:1]([CH3:2])[CH3:3])=[O:9])[CH2:23][CH2:24]1

Participants

3

Reactant 2

HCID 211002372-Isopropoxy-5-methylsulfonylbenzoic acidHCID 665702142-(Piperazin-1-yl)benzo[d]oxazole hydrochloride

Product 1

HCID 58906314(4-Benzoxazol-2-yl-piperazin-1-yl)-(2-isopropoxy-5-methanesulfonyl-phenyl)-methanone

Procedure

Prepared in analogy to example 1.1 b) from 2-isopropoxy-5-methanesulfonyl-benzoic acid (Example 2.2) and 2-piperazin-1-yl-benzoxazole hydrochloride. The crude material was triturated with diethyl ether to yield the title compound as a colorless solid.

Workup

  1. customThe crude material was triturated with diethyl ether

Sources & evidence

ORD record
ord-1b2c40df7ba74599973c4c69bb7563d6
Source dataset
uspto-grants-2008_09
Patent number
US07429585B2

Reaction notes

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