2-(Oxolan-2-yl)acetic acid → HCID 178520297, compound

Participants

Reaction Steps

The title compound, white solid (72 mg, 65%), MS (ISP) m/z=441.5 [(M+H)+], mp 192° C., was prepared in accordance with the general method of example 1 from trans-4-{2-[4-(2,3-dihydro-benzofuran-4-yl)-piperidin-1-yl]-ethyl}-cyclohexylamine dihydrochloride (intermediate B) (100 mg, 0.25 mmol) and rac-2-(tetrahydro-furan-2-yl)-acetic acid.

Provenance & Evidence