6-Methylnicotinic acid → HCID 178425856, compound

Participants

Reaction Steps

The title compound, off-white solid (77 mg, 69%), MS (ISP) m/z=448.4 [(M+H)+], mp 202° C., was prepared in accordance with the general method of example 1 from trans-4-{2-[4-(2,3-dihydro-benzofuran-4-yl)-piperidin-1-yl]-ethyl}-cyclohexylamine dihydrochloride (intermediate B) (100 mg, 0.25 mmol) and 6-methyl-nicotinic acid.

Provenance & Evidence