(R)-Tetrahydro-3-furoic acid → HCID 178523603, compound

Participants

Reaction Steps

The title compound, off-white solid (80 mg, 75%), MS (ISP) m/z=427.3 [(M+H)+], mp 211° C., was prepared in accordance with the general method of example 1 from trans-4-{2-[4-(2,3-dihydro-benzofuran-4-yl)-piperidin-1-yl]-ethyl}-cyclohexylamine dihydrochloride (intermediate B) (100 mg, 0.25 mmol) and (RS)-tetrahydro-furan-3-carboxylic acid.

Provenance & Evidence