(+-)-Tetrahydro-2-furoic acid → HCID 178523600, compound

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Reaction Steps

The title compound, white solid (87 mg, 82%), MS (ISP) m/z=427.4 [(M+H)+], mp 160° C., was prepared in accordance with the general method of example 1 from trans-4-{2-[4-(2,3-dihydro-benzofuran-4-yl)-piperidin-1-yl]-ethyl}-cyclohexylamine dihydro chloride (intermediate B) (100 mg, 0.25 mmol) and (RS)-tetrahydro-furan-2-carboxylic acid.

Provenance & Evidence