Oxane-3-carboxylic acid → HCID 178523601, compound

Participants

Reaction Steps

The title compound, off-white solid (91 mg, 83%), MS (ISP) m/z=441.4 [(M+H)+], mp 222° C., was prepared in accordance with the general method of example 1 from trans-4-{2-[4-(2,3-dihydro-benzofuran-4-yl)-piperidin-1-yl]-ethyl}-cyclohexylamine dihydro chloride (intermediate B) (100 mg, 0.25 mmol) and (RS)-tetrahydro-pyran-3-carboxylic acid.

Provenance & Evidence