Acetic Acid → HCID 178474962, compound

HRID 331464Notes

Reaction equation

HRID 331464 reaction equation
Cl.Cl.[F:3][C:4]1[C:12]2[O:11][CH:10]=[CH:9][C:8]=2[C:7]([CH:13]2[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]3[CH2:26][CH2:25][C@H:24]([NH2:27])[CH2:23][CH2:22]3)[CH2:15][CH2:14]2)=[CH:6][CH:5]=1.[C:28](O)(=[O:30])[CH3:29]>>[F:3][C:4]1[C:12]2[O:11][CH:10]=[CH:9][C:8]=2[C:7]([CH:13]2[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]3[CH2:22][CH2:23][C@H:24]([NH:27][C:28](=[O:30])[CH3:29])[CH2:25][CH2:26]3)[CH2:15][CH2:14]2)=[CH:6][CH:5]=1

Participants

3

Reactant 2

HCID 176Acetic AcidHCID 178478711HCID 178478711, compound2×

Product 1

HCID 178474962HCID 178474962, compound

Procedure

The title compound, white solid (60 mg, 62%), MS (ISP) m/z=387.3 [(M+H)+], mp 203.5° C., was prepared in accordance with the general method of example 1 from trans-4-{2-[4-(7-fluoro-benzofuran-4-yl)-piperidin-1-yl]-ethyl}-cyclohexylamine dihydrochloride (intermediate C) (104 mg, 0.25 mmol) and acetic acid.

Sources & evidence

ORD record
ord-20ce8718768941e3bb9444a0990482a3
Source dataset
uspto-grants-2014_11
Patent number
US08877778B2

Reaction notes

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