4-tert-Butylbenzoic acid → HCID 178440967, compound

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Reaction Steps

The title compound, light yellow solid (98 mg, 80%), MS (ISP) m/z=489.4 [(M+H)+], mp 208° C., was prepared in accordance with the general method of example 1 from trans-4-{2-[4-(2,3-dihydro-benzofuran-4-yl)-piperidin-1-yl]-ethyl}-cyclohexylamine dihydrochloride (intermediate B) (100 mg, 0.25 mmol) and 4-tert-butyl-benzoic acid.

Provenance & Evidence