4,4,4-Trifluorobutanoic acid → HCID 178520630, compound

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Reaction Steps

The title compound, white solid (79 mg, 70%), MS (ISP) m/z=453.3 [(M+H)+], mp 200° C., was prepared in accordance with the general method of example 1 from trans-4-{2-[4-(2,3-dihydro-benzofuran-4-yl)-piperidin-1-yl]-ethyl}-cyclohexylamine dihydro chloride (intermediate B) (100 mg, 0.25 mmol) and 4,4,4-trifluoro-butyric acid.

Provenance & Evidence