Pentanoic Acid → HCID 178447379, compound

HRID 331476Notes

Reaction equation

HRID 331476 reaction equation
Cl.Cl.[O:3]1[C:7]2[CH:8]=[CH:9][CH:10]=[C:11]([CH:12]3[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][C@H:20]4[CH2:25][CH2:24][C@H:23]([NH2:26])[CH2:22][CH2:21]4)[CH2:14][CH2:13]3)[C:6]=2[CH2:5][CH2:4]1.[C:27](O)(=[O:32])[CH2:28][CH2:29][CH2:30][CH3:31]>>[O:3]1[C:7]2[CH:8]=[CH:9][CH:10]=[C:11]([CH:12]3[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][C@H:20]4[CH2:21][CH2:22][C@H:23]([NH:26][C:27](=[O:32])[CH2:28][CH2:29][CH2:30][CH3:31])[CH2:24][CH2:25]4)[CH2:14][CH2:13]3)[C:6]=2[CH2:5][CH2:4]1

Participants

3

Reactant 2

HCID 7991Pentanoic AcidHCID 178478710HCID 178478710, compound2×

Product 1

HCID 178447379HCID 178447379, compound

Procedure

The title compound, white solid (77 mg, 75%), MS (ISP) m/z=413.4 [(M+H)+], mp 186° C., was prepared in accordance with the general method of example 1 from trans-4-{2-[4-(2,3-dihydro-benzofuran-4-yl)-piperidin-1-yl]-ethyl}-cyclohexylamine dihydro chloride (intermediate B) (100 mg, 0.25 mmol) and pentanoic acid.

Sources & evidence

ORD record
ord-e15a68f174c544b183fd67f3aac73a67
Source dataset
uspto-grants-2014_11
Patent number
US08877778B2

Reaction notes

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