2-Cyclopentyloxy-5-methanesulfonyl-benzoic acid → (2-Cyclopentyloxy-5-methanesulfonyl-phenyl)-[4-(5-ethanesulfonyl-benzoxazol-2-yl)-piperazin-1-yl]-methanone

HRID 33148Notes

Reaction equation

HRID 33148 reaction equation
[CH:1]1([O:6][C:7]2[CH:15]=[CH:14][C:13]([S:16]([CH3:19])(=[O:18])=[O:17])=[CH:12][C:8]=2[C:9]([OH:11])=O)[CH2:5][CH2:4][CH2:3][CH2:2]1.Cl.[CH2:21]([S:23]([C:26]1[CH:27]=[CH:28][C:29]2[O:33][C:32]([N:34]3[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]3)=[N:31][C:30]=2[CH:40]=1)(=[O:25])=[O:24])[CH3:22]>>[CH:1]1([O:6][C:7]2[CH:15]=[CH:14][C:13]([S:16]([CH3:19])(=[O:18])=[O:17])=[CH:12][C:8]=2[C:9]([N:37]2[CH2:38][CH2:39][N:34]([C:32]3[O:33][C:29]4[CH:28]=[CH:27][C:26]([S:23]([CH2:21][CH3:22])(=[O:25])=[O:24])=[CH:40][C:30]=4[N:31]=3)[CH2:35][CH2:36]2)=[O:11])[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

3

Reactant 2

HCID 211002232-Cyclopentyloxy-5-methanesulfonyl-benzoic acidHCID 688960685-Ethanesulfonyl-2-piperazin-1-yl-benzoxazole hydrochloride

Product 1

HCID 58906310(2-Cyclopentyloxy-5-methanesulfonyl-phenyl)-[4-(5-ethanesulfonyl-benzoxazol-2-yl)-piperazin-1-yl]-methanone

Procedure

Prepared in analogy to example 1.1 b) from 2-cyclopentyloxy-5-methanesulfonyl-benzoic acid (Example 2.3) and 5-ethanesulfonyl-2-piperazin-1-yl-benzoxazole hydrochloride. The crude material was purified by chromatography (SiO2, ethyl acetate) to yield the title compound as a colorless solid.

Workup

  1. customThe crude material was purified by chromatography (SiO2, ethyl acetate)

Sources & evidence

ORD record
ord-5503c30ef5834086b2673b6c0316c85a
Source dataset
uspto-grants-2008_09
Patent number
US07429585B2

Reaction notes

Loading…