Methyl 3-oxetaneacetate → HCID 178520364, compound

Participants

Reaction Steps

The title compound, white solid (66 mg, 62%), MS (ISP) m/z=427.4 [(M+H)+], mp 197° C., was prepared in accordance with the general method of example 81 from trans-4-{2-[4-(2,3-dihydro-benzofuran-4-yl)-piperidin-1-yl]-ethyl}-cyclohexylamine dihydrochloride (intermediate B) (100 mg, 0.25 mmol) and methyl 2-(oxetan-3-yl)acetate.

Provenance & Evidence