3-Methyl-2-butenoic acid → HCID 178447376, compound

Participants

Reaction Steps

The title compound, white solid (84 mg, 82%), MS (ISP) m/z=411.4 [(M+H)+], mp 177° C., was prepared in accordance with the general method of example 1 from trans-4-{2-[4-(2,3-dihydro-benzofuran-4-yl)-piperidin-1-yl]-ethyl}-cyclohexylamine dihydrochloride (intermediate B) (100 mg, 0.25 mmol) and 3-methyl-but-2-enoic acid.

Provenance & Evidence