2-Butynoic acid → HCID 178454552, compound

Participants

Reaction Steps

The title compound, white solid (64 mg, 65%), MS (ISP) m/z=395.3 [(M+H)+], mp 195° C., was prepared in accordance with the general method of example 1 from trans-4-{2-[4-(2,3-dihydro-benzofuran-4-yl)-piperidin-1-yl]-ethyl}-cyclohexylamine dihydrochloride (intermediate B) (100 mg, 0.25 mmol) and but-2-ynoic acid.

Provenance & Evidence