HRID331488

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID535302

4-tert-Butoxybenzoic Acid

C11H14O3

结构：Cl.Cl.N[C@H]1CC[C@H](CCN2CCC(c3cccc4c3CCO4)CC2)CC1

HCID178478710

未命名化合物

2 次

PRODUCTS

生成物

结构：CC(C)(C)Oc1ccc(C(=O)N[C@H]2CC[C@H](CCN3CCC(c4cccc5c4CCO5)CC3)CC2)cc1

HCID178450178

未命名化合物

PROCEDURE

实验过程

The title compound, white solid (74 mg, 59%), MS (ISP) m/z=505.3 [(M+H)+], mp 216° C., was prepared in accordance with the general method of example 1 from trans-4-{2-[4-(2,3-dihydro-benzofuran-4-yl)-piperidin-1-yl]-ethyl}-cyclohexylamine dihydrochloride (intermediate B) (100 mg, 0.25 mmol) and 4-tert-butoxy-benzoic acid.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-50c05738dbd8476da56a5814812c9e89
来源数据集: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08877778B2
来源说明: uspto-grants-2014_11

反应 SMILES

Cl.Cl.[O:3]1[C:7]2[CH:8]=[CH:9][CH:10]=[C:11]([CH:12]3[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][C@H:20]4[CH2:25][CH2:24][C@H:23]([NH2:26])[CH2:22][CH2:21]4)[CH2:14][CH2:13]3)[C:6]=2[CH2:5][CH2:4]1.[C:27]([O:31][C:32]1[CH:40]=[CH:39][C:35]([C:36](O)=[O:37])=[CH:34][CH:33]=1)([CH3:30])([CH3:29])[CH3:28]>>[C:27]([O:31][C:32]1[CH:33]=[CH:34][C:35]([C:36]([NH:26][C@H:23]2[CH2:22][CH2:21][C@H:20]([CH2:19][CH2:18][N:15]3[CH2:16][CH2:17][CH:12]([C:11]4[C:6]5[CH2:5][CH2:4][O:3][C:7]=5[CH:8]=[CH:9][CH:10]=4)[CH2:13][CH2:14]3)[CH2:25][CH2:24]2)=[O:37])=[CH:39][CH:40]=1)([CH3:30])([CH3:28])[CH3:29]