HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 331516Generated: October 30, 2026
Iodoethane → 2-Ethyl-2-(4-iodo-2-pyridyl)butanenitrile
https://huagongshe.com/reaction/331516
Participants
| Role | Name | HCID | Charge |
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| Reactant | Iodoethane | HCID 6340 | — |
| Reactant | 4-[4-[5-Amino-6-[3-[4-(methylaminomethyl)phenyl]isoxazol-5-yl]pyrazin-2-yl]-2-pyridyl]tetrahydropyran-4-carbonitrile | HCID 70818655 | — |
| Reactant | 2-(4-Iodo-2-pyridyl)butanenitrile | HCID 70818698 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-Ethyl-2-(4-iodo-2-pyridyl)butanenitrile | HCID 70818747 | 100% |
Reaction Steps
Crude 2-(4-iodo-2-pyridyl)butanenitrile (270 mg, 0.9923 mmol) was added to a solution of iodoethane (309.6 mg, 158.8 μL, 1.985 mmol) and bis(trimethylsilyl)azanide (sodium ion (1)) (992.3 μL of 1 M, 0.9923 mmol) in toluene (2 mL) at 0° C. The solution was stirred at 0° C. for 10 minutes. Reaction mixture was diluted with water and the product extracted with dichloromethane (×3). Organic extracts were combined, dried over MgSO4, filtered and concentrated in vacuo. (297.8 mg, assumed 100% yield). LC/MS m/z 301.02 [M+H]+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08877759B2 |
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| Source dataset | uspto-grants-2014_11 |
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| ORD ID | ord-447bf177edba45f2ab934bf213c5ca3b |
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| Source note | uspto-grants-2014_11 |
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